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CONCENTRATED VITAMIN A SOLUTION

Maternal and Child Health

Concentration of vitamin A in the solution
1,00,000 IU per mL

Which is the oil used
Arachis oil (peanut oil)

A total of how many doses are recommended.
Nine doses till 5 years of age.

The spoon supplied with the bottle has amarking inside. This indicates a volume of 1 mL.Completely filled spoon measures 2 mL.

Whether part of NIS?
Yes

Mention the dosage schedule under NIS.

  1. First dose is 1 mL (1 lakh units) at 9 months of age. This is given along with the MR-1, PCV-Booster and JE-1(if applicable) which are also administered at the same age.
  2. Second dose is 2 mL (2 lakh units) at 16-24 months of age. This is given along with DPT and OPV boosters, MR – 2 and JE – 2 (if applicable).
  3. The 3rd, 4th, 5th, 6th, 7th, 8th, and 9th doses of 2 mL each at 6 monthly intervals beginning 6 months after the second dose

How many prophylactic doses of vitamin A should be given and till what age under the national program?
A total of nine prophylactic doses of vitamin A should be given till 5 years of age.

What should be the minimum gap between two doses of vitamin A and why?
The minimum gap between any two doses of vitamin A should be 6 months as the liver can store enough vitamin A for 6-9 months. Too frequent doses may lead to vitamin A toxicity.

How do we ensure that the health worker delivers the correct dose to the child?
Vitamin A syrup has to be administered using only the spoon which is provided with each bottle. The inner mark in the spoon indicates a volume of 1 mL which is equivalent to 1,00,000 IU and a level full spoon has a capacity of 2 mL which is equivalent to 2,00,000 IU of vitamin A.
Spoon for Vit A syrup
Is the dose any different for those children who show clinical signs of vitamin A deficiency?
Administer 2,00,000 IU of vitamin A immediately after diagnosis, followed by another dose of 2,00,000 IU 1–4 weeks later.

Storage instructions
Vitamin A solution must be kept away from direct sunlight and should be used only till the expiry date printed on the bottle.

Mention natural sources of vitamin A.

  • Eggs, liver, fish, and meat

  • Dairy products such as milk, cheese, curd, and butter

  • Fruit rich in vitamin A

  • Papaya

  • Mango

  • Oranges

  • Vegetables rich in vitamin A

  • Green leafy vegetables such as spinach

  • Carrots

  • Pumpkin

Mention the richest natural source of vitamin A.
Fish liver oils

Mention the manifestations of vitamin A deficiency.
Ocular signs

  • Night blindness (nyctalopia)
  • Conjunctivalxerosis
  • Bitot's spots
  • Corneal xerosis
  • Keratomalacia

Extraocular manifestations of vitamin A deficiency

  • Follicular hyperkeratosis
  • Anorexia
  • Growth retardation
  • Susceptibility to respiratory and intestinal infections

What is the aim of the oral vitamin A prophylaxis program?
The revised objective is to decrease the prevalence of vitamin A deficiency to below 0.5%.

What are the other strategies for achieving the reduction of vitamin A deficiency?

  • Improving peoples' diet to ensure adequate intake of vitamin A rich food.
  • Encourage early breastfeeding especially the colostrum which is rich in vitamin A.
  • Controlling the frequency and severity of factors which contribute to vitamin A deficiency, such as measles, diarrhea, PEM, and respiratory tract infections.

References:

  1. Park K. Nutrition and health. In: Park's Textbook of Preventive and Social Medicine, 24th ed. Jabalpur, India: M/S BanarasidasBhanot Publishers, 2017.

National Immunization Schedule in India; 2017

Rotavirus vaccine: ROTAVIRUS VACCINE - Rotavac

PENTAVALENT VACCINE

BACILLE CALMETTE GUERIN (BCG) VACCINE

IPV (INACTIVATED POLIOVIRUS VACCINE)

DT & TT Vaccines: DPT AND TT VACCINES

**Oral Polio Vaccines (OPV)**: Oral Polio Vaccines (OPV)

Measles Containing Vaccines (MCV)

HEPATITIS B VACCINE

JAPANESE ENCEPHALITIS (JE) VACCINE

Pneumococcal Conjugate Vaccine (PCV)

RABIES VACCINE

CONCENTRATED VITAMIN A SOLUTION

VACCINE VIAL MONITOR (VVM)

Adverse event following immunization (AEFI)